Clinically proven ways to help prevent and correct hyperpigmentation
Published on 12 March 2026
Hyperpigmentation can be persistent, particularly when influenced by multiple triggers such as sun exposure, inflammation and hormonal changes.
Because of this complexity, many dermatologists recommend skincare supported by clinical evidence when addressing uneven skin tone. Clinical testing helps demonstrate whether formulations can produce measurable improvements in dark spots, skin texture and overall radiance.
NEORETIN Pigment Neutraliser Serum
NEORETIN Pigment Neutraliser Serum is a lightweight daily treatment designed to visibly improve uneven skin tone while supporting overall skin clarity.
The formula combines several targeted ingredients, including:
- Azelaic acid in AOX-Tech®
- Bakuchiol
- Azeloglycine
- Hyaluronic acid
Together, these ingredients help regulate pigment formation while delivering antioxidant protection and hydration.
Key benefits
The serum helps to:
- Reduce the appearance of dark spots and uneven tone
- Support skin renewal and brightness
- Calm inflammation that can contribute to pigmentation
- Provide hydration and antioxidant protection
- Suit all skin types, including sensitive skin
Because of its balanced formulation, the serum can also be suitable for individuals who struggle to tolerate stronger retinoids or exfoliating acids.
Clinical study results
Clinical testing has demonstrated visible improvements in skin tone following consistent use of NEORETIN Pigment Neutraliser Serum.
In a clinical study involving 22 women aged 30–60 who applied the serum twice daily for 56 days1:
- 100% reported brighter, more radiant skin
- 95% noticed improved skin texture and a more even tone
- 86% saw a visible reduction in dark spots
Additional measurements also showed improvements in skin hydration and barrier function, supporting overall skin health.
NEORETIN Pigment Corrector Peel Pads
NEORETIN Pigment Corrector Peel Pads are designed to complement depigmenting treatments by promoting controlled exfoliation and accelerated skin renewal.
Used once weekly, the pads deliver triple exfoliation - chemical, enzymatic and mechanical - to remove dead skin cells and encourage skin renewal.
Each pure fibre pad is saturated in a concentrated formula and features a lightly textured surface that enhances exfoliation during application.
Key ingredients
The formula combines several brightening ingredients, including:
- Retinol delivered through RetinSphere® Technology
- Glycolic acid
- Kojic acid
- Niacinamide
Together, these ingredients help improve pigmentation while smoothing skin texture and enhancing overall radiance.
Clinical study results
Clinical testing has shown that the peel pads can produce a 23% reduction in visible dark spots after just one use2, demonstrating their powerful renewing action.
When used regularly alongside the NEORETIN Pigment Neutraliser Serum, they help support clearer, brighter skin over time.
Expert testimonial
Beauty editor Tracy Achonwa of Vogue highlighted the effectiveness of the peel pads after several weeks of use:
“You get six pads in a pack, but that is plenty considering how powerfully these work. I used one a week for just over a month and was pleasantly surprised to find my skin felt softer and my dark marks had faded significantly. The genius of this formula is that it uses glycolic acid to penetrate skin deeply, improving the absorption of bonus skin brighteners like kojic acid that stop excess melanin in its tracks.”
Customer feedback
Many users also report visible improvements after incorporating NEORETIN into their skincare routine:
“My skin looks noticeably brighter and more even after a few weeks.”
“Dark marks from old breakouts have faded much faster than I expected.”
“Gentle enough for my sensitive skin but still really effective.”
Visible results with NEORETIN
Hyperpigmentation can take time to improve, but consistent use of targeted skincare and daily sun protection can make a visible difference.
Through a combination of RetinSphere® Technology, azelaic acid in AOX-Tech® and clinically proven brightening ingredients, NEORETIN helps regulate melanin production, accelerate skin renewal and visibly improve skin tone.
With continued use, it can help reduce the appearance of dark spots, smooth skin texture and restore a brighter, more even complexion.
To understand the science behind pigmentation and the ingredients that help treat it, read our guide to what causes hyperpigmentation and how to treat it effectively.
